Julvi Hus i Göteborg AB. 031497575. Ingela Gathenhielms Gata 5. 421 30, VÄSTRA FRÖLUNDA. Dalkia Energy and Industrial Services AB. 0214982011.
The sodium taurocholate cotransporting polypeptide (NTCP) is expressed at the basolateral membrane of hepatocytes, where it mediates the uptake of conjugated bile acids and forms the hepatocyte entry receptor for the hepatitis B and D virus. Here, we aimed to identify novel protein–protein interactions that could play a role in the regulation of NTCP. To this end, NTCP was precipitated
Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypept …. Bile salts are the major organic solutes in It has been proposed that the hepatocellular Na (+)-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes. In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver Na (+)-taurocholate cotransporting polypeptide (Ntcp) may transport only taurocholate. the SLC10 sodium bile salt cotransporters Na+/taurocholate cotransporting polypeptide (NTCP) and the apical sodium-dependent bile salt transporter (ASBT). While expression of NTCP is restricted to 1987-03-30 The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well.
Electrogenicity of the primary bile salt transport process, Na-bile salt cotransport, has been difficult to determine because the large K and Cl conductances of the sinusoidal membrane (GK and GCl, respectively) obscure any transport associated currents. 2003-07-08 Bile salts are the major organic solutes in bile and undergo extensive enterohepatic circulation. Hepatocellular bile salt uptake is mediated predominantly by the Na(+)-taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na(+)-independent organic anion-transporting polypept …. Bile salts are the major organic solutes in It has been proposed that the hepatocellular Na (+)-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes. In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver Na (+)-taurocholate cotransporting polypeptide (Ntcp) may transport only taurocholate.
1991-12-01
Na+-dependent bile salt transport system in the hepatocytes of the adult lamprey, with a very low affinity for TCA (K m = 115 ± 8.7 µM). This is strikingly different from previous observations in isolated hepatocytes from skate and rainbow trout1,2 that appear to lack a Na+-dependent TCA transporter. 2000-04-01 · In addition to sodium/bile salt cotransport, sodium-independent bile salt transport pathways are also present at the basolateral plasma membranes of hepatocytes (8, 9, 11).
1987-03-30
Other transported 3.
u 1987 Academic Press, Inc. Bile salts are reabsorbed in proximal tubules of rat kidney against a concentration gradient by a Na+-dependent transport system (1). The pre-S1 domain of the large HBsAg protein promotes attachment and entry of HBV into the hepatocyte via liver cell–specific receptor recently identified as Na (sodium) taurocholate cotransporting polypeptide (NTCP), which is an integral membrane protein used in bile acid transport.
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Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. 12 Nov 1997 dent bile salt uptake, the physiological and biochemical proper-. 1); 4) Na/- coupled bile salt cotransport is selectively present in differentiated SOLUTE CARRIER FAMILY 10 (SODIUM/BILE ACID COTRANSPORTER FAMILY) The SLC10A1 gene encodes a transporter of conjugated bile salts from the Abstract Bile salts are the major organic solutes in bile and undergo extensive bile salt uptake is mediated predominantly by the Na+-taurocholate cotransport 5 Mar 2021 This gene encodes a sodium/bile acid cotransporter. Among its related pathways are Bile secretion and Synthesis of bile acids and bile salts. bile salts into hepatocytes is not known.
The Na+/bile salt co-transporter of the pig ileal brush border membrane has been expressed in Xenopus laevis oocytes. Injection of pig ileal poly (A)+ RNA into oocytes resulted in the functional expression of an Na(+)-gradient-stimulated taurocholate uptake within 2-5 days. The expressed Na(+)-dependent taurocholate uptake exhibited saturation kinetics (apparent Km of 48 microM), and displayed
2021-04-01 · The reuptake of bile salts by the SLC10A1 transporter concludes the enterohepatic cycle of bile salt circulation (summary by Vaz et al., 2015). Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids.
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2003-07-08
u 1987 Academic Press, Inc. Bile salts are reabsorbed in proximal tubules of rat kidney against a concentration gradient by a Na+-dependent transport system (1). The pre-S1 domain of the large HBsAg protein promotes attachment and entry of HBV into the hepatocyte via liver cell–specific receptor recently identified as Na (sodium) taurocholate cotransporting polypeptide (NTCP), which is an integral membrane protein used in bile acid transport. 23,24 There is evidence that hepatocyte entry may be a multistep process including binding to heparan sulfate ASBT is Na-dependent uptake transporter of bile acids and conjugates.
Sodium/bile acid cotransporters are integral membrane glycoproteins. Human NTCP contains 349 amino acids and has a mass of 56 kDa. Function. Bile acid:sodium symporters participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids.
How-ever, these correlations have ABCB11, a bile salt export pump, has been identified as the major canalicular bile salt-transporting protein, and the mutations in ABCB11 cause progressive familial intrahepatic cholestasis 2 [69]. It was revealed that knockout of PPARα decreases hepatic ABCB11 levels in mice, leading to the accumulation of bile acids in the liver following cholic acid dietary challenge [40] .
In rat liver, Na+- 2002-01-01 The Bulletin, MDI Biological Laboratory V. 52, 2013 20 Characterization of a bile salt transport system in isolated hepatocytes from adult sea lamprey (Petromyzon marinus) Shi-Ying Cai1, Alison Pierik2 and James L. Boyer1,2 1 Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 2 Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672 2008-03-28 The Bulletin, MDI Biological Laboratory V. 53, 2014 4 Characterization of a bile salt transport system in isolated hepatocytes from adult sea lamprey (Petromyzon marinus) Shi-Ying Cai1, Daniël A. Lionarons1, and James L. Boyer1,2 1 Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 2 Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672 Although less is known about bile salt transport in the kidney, bile salts that escape first-pass clearance by the liver after reabsorption from the intestine are filtered at the glomerulus, where they are thought to be reabsorbed by a sodium-dependent bile salt transport mechanism in the proximal convoluted tubule.18–20 Thus, under nor-mal conditions, bile salt losses in urine are minimal. It has been proposed that the hepatocellular Na(+)-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes. In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver Na(+)-taurocholate cotransporting polypeptide (Ntcp) may transport only taurocholate. 1 ways to abbreviate Na(+)-bile Salt Co-transporter.